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STATINSpgx

Statin drugs pharmacogenetics testing
DNA test of statin drugs
Adequate response to statin treatment. DNA test that analyzes polymorphisms of different genes involved in the metabolism of statins in order to know the risk that cholesterol will not be lowered and/or to suffer myopathies.
Precio: 
299 €

Sample type:

Saliva

Delivery period:

30 - 40 days from sample receipt.
Last update of the document Apr, 02/04/2024 - 12:22

Statins are drugs used to lower blood cholesterol levels. They act by inhibiting an enzyme: HMG-CoA reductase, which is one of the key points in the synthesis of cholesterol.

However they also inhibit many other metabolites, adding other beneficial effects to its use, such an antioxidant, anti-inflammatory, endothelium stabilizing and antithrombotic actions.

But this inhibition may be the cause of adverse effects, which the most frequent is muscle pain (myopathy).

Under normal conditions, statins enter the liver, exert their cholesterol-lowering action and are transformed to be eliminated in the urine. About 25 % of people have a genetic substitution that prevents statins from entering statins as normal.

Not being eliminated, statin levels increase in blood and penetrate the muscle, where they inhibit the synthesis of coenzyme Q10. This is a key molecule in the electron transport chain in the mitochondria, which is the basis of energy production in the muscle. When there is a Co-Q10 deficit, there is a reduced ATP synthesis and more free radicals are generated.

Statins are indicated to lower cholesterol and prevent cardiovascular diseases. There are people who experience muscle pain or weakness.  Symptoms sometimes serious, which often are not associated to statins treatment. A genomic study avoids these side effects and contraindications to other drugs.

STATINSpgx includes an interpretation of the results for the most common prescription drugs that can be used immediately without other tools.

Interpretation of the report in polytherapy

In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.

However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.

Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.

Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.

Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.

g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.

This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Required documents
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Fill in the documents that we will send you, duly signed. You can also find these documents on this page, under the web tab: "Documents required".
  2. Follow the instructions for collecting the sample.
  3. After obtaining the sample, include it in the return envelope remember to put into the necessary documents.
  4. Call Eugenomic® on +34 93 292 29 63 or email info@eugenomic.com to request sample collection. No shipping costs on Spanish territory.
  5. An email confirmation will be sent when your sample si received.
  6. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results"

Info producto mobile

Profile Information

Statins are drugs used to lower blood cholesterol levels. They act by inhibiting an enzyme: HMG-CoA reductase, which is one of the key points in the synthesis of cholesterol.

However they also inhibit many other metabolites, adding other beneficial effects to its use, such an antioxidant, anti-inflammatory, endothelium stabilizing and antithrombotic actions.

But this inhibition may be the cause of adverse effects, which the most frequent is muscle pain (myopathy).

Under normal conditions, statins enter the liver, exert their cholesterol-lowering action and are transformed to be eliminated in the urine. About 25 % of people have a genetic substitution that prevents statins from entering statins as normal.

Not being eliminated, statin levels increase in blood and penetrate the muscle, where they inhibit the synthesis of coenzyme Q10. This is a key molecule in the electron transport chain in the mitochondria, which is the basis of energy production in the muscle. When there is a Co-Q10 deficit, there is a reduced ATP synthesis and more free radicals are generated.

Statins are indicated to lower cholesterol and prevent cardiovascular diseases. There are people who experience muscle pain or weakness.  Symptoms sometimes serious, which often are not associated to statins treatment. A genomic study avoids these side effects and contraindications to other drugs.

STATINSpgx includes an interpretation of the results for the most common prescription drugs that can be used immediately without other tools.

Interpretation of the report in polytherapy

In this report, the "green" labeling of a certain drug with the patient's genes indicates that it can be prescribed in the standard dose conditions disclosed in the prospectus or those recommended by the physician. This applies in the case of monotherapy.

However, if the patient takes several medications, which is very common, although in the report would appear in "green" can cause adverse effects due to possible interactions between them, which can sometimes be severe, either by toxicity or by therapeutic failure.

Drugs are chemicals that may interfere the normal metabolism of other drugs. Interferences that are also applicable to the chemical substances of various medicinal plants and food supplements.

Consequently, the whole of the medication, together with the consumer products or life habits of the patient, must undergo an evaluation of pharmacological interactions.

Consulting g-Nomic® Pharmacogenetics interpretation software, before prescribing, is an effective aid to avoid most adverse effects or therapeutic failures due to medication.

g-Nomic® interrelates all drugs, herbs, nutritional supplements and lifestyle, with the patient's genes. It also advises the most appropriate dose to prescribe.

This text has been translated automatically using an electronic translator, so the Spanish version should prevail. Please check in case of doubt.

Sample type and process to follow

You will receive the sample collection kit. You can request additional kits if you need it.

Sample collection kit content:
You will get a box with sample collection kit. Within the kit you will find:

  1. Saliva collector.
  2. Instructions for the sample collection.
  3. Required documents
  4. Security bag to enter the sample for shipment.
  5. Envelope bag.

Process to follow:

  1. Fill in the documents that we will send you, duly signed. You can also find these documents on this page, under the web tab: "Documents required".
  2. Follow the instructions for collecting the sample.
  3. After obtaining the sample, include it in the return envelope remember to put into the necessary documents.
  4. Call Eugenomic® on +34 93 292 29 63 or email info@eugenomic.com to request sample collection. No shipping costs on Spanish territory.
  5. An email confirmation will be sent when your sample si received.
  6. When the study will be completed you will receive a new e-mail to inform you that your report is already available in "My results"

Documentación